desubstantiate,v.|diːsʌbˈstænʃɪeɪt| [f. de- II. 1 + L. substāntia substance + -ate: after substantiate.] trans. To deprive of substance. 1884Mrs. H. Ward tr.Amiel's Jrnl. (1891) 255 The mind is not only unclothed but stripped of itself and so to speak de-substantiated.