| 释义 |
synthalin Pharm.|ˈsɪnθəlɪn|
[a. G. synthalin (E. Frank et al. 1926, in Klin. Wochenschr. 5 Nov. 2101/1), f. synth-etisch synthetic a. + -a- + insu-lin insulin.]
A synthetic but toxic aliphatic diguanidine which has the hypoglycæmic effect of insulin when taken orally; decamethylene-diguanidine, H2N·C(NH)·NH·(CH2)10·NH·C(NH)·NH2; also called synthalin A; synthalin B, an analogous compound in which {b1}(CH2)10{b1} is replaced by {b1}(CH2)12{b1}.
1927Chem. Abstr. XXI. 772 To produce a molecule of min. toxicity and max. insulin activity, further changes were made in the mol...which resulted finally in a deriv. that is called Synthalin. 1936Hill & Howitt Insulin ix. 190 The decided differences between the action of both synthalin and synthalin-B and insulin render even these substances doubtful as effective substitutes for the hormone. 1952,1961[see diguanidine]. 1980J. Crossland Lewis's Pharmacol. (ed. 5) lvi. 878/1 In the early 1920's..it was found that a number of aliphatic diguanidines such as the Synthalins A and B..produced hypoglycaemia in man. |