| 释义 |
taxol, n. Chem. and Pharmacol.
Brit. |ˈtaksɒl|, U.S. |ˈtæksɔl|, |ˈtæksɑl|
Forms: also with capital initial.
[‹ scientific Latin Taxus, genus name (see taxane n.) + -ol suffix.]
A taxane, C47H51NO14, originally isolated from the bark of the Pacific yew, Taxus brevifolia, and later found to have antimitotic and antineoplastic activity. Later also: (a proprietary name for) the drug paclitaxel, based on this compound.
1971M. C. Wani et al. in Jrnl. Amer. Chem. Soc. 93 2325/1 We wish to report on the structure of a novel compound named taxol.., isolated from the stem bark of the Western yew, Taxus brevifolia. 1981Biochemistry 20 1318/2 The other probe was taxol, a low molecular weight neutral plant product which has antitumor activity. 1989Ann. Internal Med. 111277/1 Mucositis was a prominent toxicity in studies using higher doses of taxol in patients with acute leukemia. 1995Equinox Feb. 54/3 The yew has bark that contains paclitaxel, the active ingredient in Taxol, a high-priced medication with a successful record of treating breast and ovarian cancer. 2000J. C. McAuliffe & O. Hindsgaul in M. Fukuda & O. Hindsgaul Molecular & Cellular Glycobiol. viii. 272 A sialylated version of taxol. 2002Times 5 Apr. 28/5 Taxol..is now off-patent and is suffering aggressive generic competition. |