| 释义 |
ergotamine Biochem.|ɜːˈgɒtəmiːn, -ɪn|
[ad. G. ergotamin (Spiro & Stoll 1921, in Actes Soc. Helv. Sci. Nat. 1920 235), f. ergot + amine.]
An alkaloid, C33H35O5N5, present in some kinds of ergot and used chiefly in the treatment of migraine. Hence ergoˈtaminine [ad. G. ergotaminin (Spiro & Stoll 1921, in Actes Soc. Helv. Sci. Nat. 1920 236), f. ergot + amine + -ine5], a physiologically inactive ergot alkaloid, isomeric with ergotamine.
1921Brit. Pat. 170, 302 The principal alkaloid of ergot in the pure crystallised state..has since been designated..by the scientific name of ‘ergotamine’. 1922Jrnl. Chem. Soc. A. CXXII. i. 47 Ergotamine, obtained in crystallisable form from ergot, on treatment with methyl alcohol gives a new, less active alkaloid, ergotaminine. 1952L. Marion in Manske & Holmes Alkaloids II. 376 Ergotamine and ergotaminine do not seem to occur in rye ergot, but are found in other ergots such as that growing..on marrom grass. 1955[see ergonovine]. 1961New Scientist 2 Nov. 278/2 The first pure ergot alkaloids were obtained by Stoll in 1920, namely the pharmacologically-active compound ergotamine and the inactive mirror-image molecule ergotaminine. 1964S. Duke-Elder Parsons' Dis. Eye (ed. 14) xxiv. 362 Rest, warmth, and sleep are the best measures to combat the attacks [of migraine]; they can sometimes be warded off or alleviated by ergotamine tartrate. 1968J. H. Burn Lect. Notes Pharmacol. (ed. 9) 75 Ergotamine has now lost much of its importance since the discovery of ergometrine (ergonovine). |