| 释义 |
ethacrynic, a. Pharm.|ɛθəˈkraɪnɪk|
[f. eth- + acryl n. + phenoxy- + -ic, elements of the systematic name.]
ethacrynic acid, a powerful diuretic, C13H12Cl2O4 , given orally or intravenously in the treatment of oedema resulting from heart failure; (2,3-dichloro-4-(2-ethylacryloyl)phenoxy)acetic acid.
1963Brit. Med. Jrnl. 8 June 1521/1 There are occasional patients who do not respond adequately to these diuretics, and it was with these ‘resistant’ patients in mind that we investigated the diuretic properties of a new drug, ethacrynic acid (MK-595). 1965Time 19 Feb. 78/3 Ethacrynic acid, a synthetic compound discovered in 1960, has a dramatic diuretic effect even in patients who do not respond to other drugs. 1980Brit. Med. Jrnl. 29 Mar. 907/2 There are few, if any, studies with bumetanide or ethacrynic acid in which no potassium supplements were given. 1983Oxf. Textbk. Med. II. xiii. 62/2 Frusemide (furosemide), ethacrynic acid, bumetanide, and xipamide..all act principally by inhibiting chloride transport in the ascending limb of Henle's loop. 1987M. J. Neal Med. Pharmacol. xiii. 33/2 Over-enthusiastic use of loop diuretics, especially ethacrynic acid..can cause deafness. |