| 释义 |
thiazide Pharm.|ˈθaɪəzaɪd|
[f. thio- + azine + oxide, elements in the systematic name of the parent compound.]
Any of a class of drugs derived from 1,2,4-benzothiadiazine-1,1-dioxide that increase the excretion of sodium and chloride and are used as diuretics and as auxiliary hypotensive agents.
1959Jrnl. Amer. Med. Assoc. 22 Aug. 2052/2 When the thiazide derivatives are first administered to hypertensive patients being treated with other drugs, it is advisable to continue giving Rauwolfia derivatives. 1961Lancet 12 Aug. 334/1 The use of guanethidine in combination with one of the thiazide group of diuretics extends the application of these drugs in the management of patients with high blood-pressure. 1974M. C. Gerald Pharmacol. xxii. 399 When used alone, the thiazides have only weak anti⁓hypertensive effects. 1980Brit. Med. Jrnl. 18 Oct. 1053 Vasodilators are used mainly as additional treatment in patients who are not controlled by thiazides and beta-blockers. |