| 释义 |
transpeptidation Biochem.|ˌtrɑːnspɛptɪˈdeɪʃən, ˌtræns-, -nz-|
[f. trans- 10 + peptide + -ation.]
Any reaction in which a peptide bond is broken and the free carboxyl (or amino) group joined to the amino (or carboxyl) group of another molecule so as to form a new peptide bond.
1950J. S. Fruton in Yale Jrnl. Biol. & Med. XXII. 264 Reactions of this type may be termed ‘transpeptidation’ or ‘transamidation’ processes. 1975Nature 10 Apr. 482/2 Various cell-free transpeptidation systems are now known to be sensitive to penicillin.
So transˈpeptidase [-ase], any enzyme that catalyses transpeptidation.
1952C. S. Hanes et al. in Biochem. Jrnl. LI. 25/1 The enzyme will be referred to as γ-glutamyl transpeptidase. 1981Sci. Amer. June 68/1 The vulnerable enzymes are either transpeptidases (which cross-link one peptide chain of new peptidoglycan to another by displacing a terminal d-alanine) or d-carboxypeptidases (which remove a terminal d-alanine by hydrolysis without cross-linking taking place). |