| 释义 |
genotoxic, a. Biol. and Med.|dʒɛnəʊˈtɒksɪk|
[f. *geno- + toxic a.]
Designating any substance (esp. a carcinogen) which has a direct and toxic effect upon the genetic material of an organism.
1974Mutation Res. XXV. 197 The wide variety of genetic alterations that can be induced in human populations when exposed to chemical genotoxic substances..may be predictable using laboratory organisms such as yeasts. 1982Brit. Med. Jrnl. 2 Jan. 30/1 Since the hazards of vinyl chloride monomer were recognised, considerable attention has been paid..to the possibility of leaching out of potentially genotoxic monomers from plastic food containers. 1983Science 9 Dec. 1115/1 The debatable issue of genotoxic versus epigenetic carcinogens. 1987Economist 24 Oct. 110/3 There is no dispute about the danger of such ‘genotoxic’ carcinogens.
Hence genotoˈxicity n.
1980D. Brusick Princ. Genetic Toxicol. i. 5 The application of fundamental genetic methodology to human problems occurred prior to the recent concern over genotoxicity. 1988Nature 28 Apr. 782/3 For the low genotoxic carcinogens that are negative in the Ames test..the authors recommend a second genotoxicity assay. |