| 释义 |
allotypy Immunol.|ˈæləʊtɪpɪ|
[ad. F. allotypie (J. Oudin 1956, in Compt. Rend. CCXLII. 2606), f. Gr. ἄλλος allo- + τύπος type n.1: see -y3.]
The occurrence of a protein in antigenically distinct forms in different individuals of a species.
1962Nature 19 May 658/2 It would be of interest to determine if antigenic polymorphisms of β-lipoproteins (allotypy) occur in species other than man; for example, in rabbits, where allotypy for the α- and β-globulin has already been reported. 1969[see allotypically adv.]. 1972Sci. Amer. June 35/1 The immunoglobulin molecule consists of a ‘constant’ region whose amino acid composition varies among different individuals of the same species. This variation, known as allotypy, is not related to the molecule's recognition function in its role as an antibody. 1984Jrnl. Immunol. Methods LXXI. 9 An allotypy in the rat species is located on the constant part of the kappa light chain.
Hence alloˈtypic a., pertaining to or exhibiting allotypy; alloˈtypically adv.
1962Nature 25 Aug. 785 The allotypic specificity is that which is not the same for all normal individuals of the same species. 1967New Scientist 4 May 277/2 One position in the ‘invariable’ half of the [protein] chain is known in which the amino-acid may vary, being either valine or leucine. It turns out that these two alternatives (known as ‘allotypic’ alternatives) behave as genetic alleles. 1968WHO Technical Rep. Ser. No. 402. 10 Recombination of allotypic markers identified on different IgG-cistrons have [sic], however, been detected. 1969S. Sell in Smith & Good Cellular Recognition 208/1 If the control of expression of allotypy is similar for lymphocytes and for plasma cells, then each lymphocyte from an allotypically heterozygous donor should express only one of the two allotypic specificities supplied genetically. 1975Immunogenetics II. 288 Allotypically defined sublines of the B14 strain. 1984W. H. Hildemann Essent. Immunol. v. 37 Only one of two alternative allotypic markers is expressed in each mature B cell. |