| 释义 |
amantadine Pharm.|əˈmæntədiːn|
[f. alteration of adamantane + amine.]
A derivative, C10H17N.HCl, of adamantane which inhibits the action of some viruses, and is used prophylactically against influenza type A2 and also in the treatment of Parkinsonism. Also amantadine hydrochloride.
1964Science 15 May 862/1, 1-Adamantanamine (amantadine), a stable, colorless, crystalline amine with an unusual symmetrical structure, reproducibly and selectively inhibits influenza viruses in tissue culture, chick embryos, and mice. 1977Lancet 23 Apr. 904/1 It is difficult to know whether to prescribe levodopa, bromocriptine, or amantadine for patients with Parkinson's disease who also have heart-disease, because all these drugs may be cardiotoxic. 1977Martindale's Extra Pharmacopoeia (ed. 27) 855/2 Amantadine hydrochloride is an antiviral agent which probably inhibits penetration of the virus into the host cell. It has no virucidal actions. 1983New Scientist 10 Mar. 644/1 The third anti-viral drug available now is a cage-like hydrocarbon amine molecule called amantadine. |