| 释义 |
vinblastine Pharm.|vɪnˈblæstiːn|
[f. mod.L. Vin-ca, former generic name (see periwinkle1) + leuco)blast s.v. leuco- + -ine5.]
A cytotoxic alkaloid, C46H58N4O9, obtained from the periwinkle Catharanthus roseus and administered intravenously (usu. as the sulphate) in the treatment of lymphomas and other cancers. Cf. vincristine.
1962M. R. Karon et al. in Pediatrics XXX. 791/1 Several alkaloids were subsequently isolated from the crude extract [of Vinca rosea], two of which, leurosine and vinblastine (formerly called vincaleukoblastine), markedly inhibited this tumour. 1974Nature 15 Mar. 239/1 The alkaloids colchicine and vinblastine interfere with the assembly of microtubules, yet they also affect several properties of the surface membrane of animal cells. 1983Oxf. Textbk. Med. II. xix. 96/1 Vincristine..is preferable to vinblastine..in the treatment of leukaemia. |