ˈregentess [-ess.] A female regent. 1611Cotgr., Regente, the Regentesse, or Protectresse of a Kingdome.1830W. Taylor Hist.Surv.Germ. Poetry III. 318 A characteristic scene is that..between the Regentess and Macchiavel.1877Tinsley's Mag. XX. 147 Penetrating to the cabinet of the regentess.