| 释义 |
Werdnig–Hoffmann Path.|ˈvɜːdnɪg|
The names of Guido Werdnig, 19th-century Austrian neurologist, and Johann Hoffmann (Hoffmann 3), who described the disease in 1890 and 1893 respectively, used in the possessive and attrib. to designate a fatal familial disease that is present at birth or develops soon afterwards and is characterized by muscular atrophy, paralysis, and loss of sucking ability.
1903Trans. Clin. Soc. XXXVI. 226 (heading) Three cases of family progressive spinal muscular atrophy (Werdnig–Hoffmann [sic] type). 1920Brain XLIII. 170 The case was scarcely one of amyotonia congenita, but rather was related to Werdnig–Hoffmann's progressive muscular atrophy, in spite of there being no obvious element of heredity. 1978Arch. Dis. Childhood LIII. 921/1 Werdnig–Hoffmann disease—the acute severe infantile form of spinal muscular atrophy—often presents in the neonatal period with profound weakness. |