| 释义 |
Krebs Biochem.|krɛbz|
The name of Sir Hans Adolf Krebs (b. 1900), German-born British biochemist, used attrib. (or occas. in the possessive) to designate a circular sequence of enzyme-catalysed reactions occurring in mitochondria as part of cell respiration in aerobic organisms, in which an acetyl group (bound to a coenzyme and produced by glycolysis or other catabolic processes) is combined with oxaloacetic acid and then oxidized by a succession of reactions which produces carbon dioxide, serves to convert adenosine diphosphate to the energy-rich triphosphate (by means of the cytochrome system), and regenerates oxaloacetic acid.
1941Jrnl. Biol. Chem. CXXXIX. 483 Oxidation of pyruvate by the Krebs cycle involves its union with oxalacetate. 1950Chem. Abstr. XLIV. 1552 (heading) Final stage in biological oxidation processes: Krebs' tricarboxylic acid cycle. 1955New Biol. XIX. 85 The Krebs cycle is a mechanism through which the various synthetic activities of the cell mutually affect each other. 1969New Scientist 9 Oct. 64/3 Because some of the intermediate compounds in the Krebs cycle need to be bled off for other purposes, the bacillus has a special mechanism for stoking up its level from glucose. 1971Sci. Amer. May 128/2 Next are the tens or hundreds of mitochondria, the enclosures where the complicated biochemical machinery of the Krebs cycle is mounted, producing most of the cell's ATP fuel by the oxidation of small organic molecules. 1971Yudkin & Offord Harrison's Guidebk. Biochem. (new ed.) xi. 101 The Krebs cycle is responsible for the oxidation of the acetyl group of acetyl coenzyme A. |