| 释义 |
lysergic, a. Chem.|laɪˈsɜːdʒɪk|
[f. lys (in hydrolysis) + ergot n. + -ic.]
lysergic acid: a. A crystalline tetracyclic compound, C16H16N2O2, containing the indole nucleus and occurring in two enantiomorphic forms, the dextrorotatory one being produced by the hydrolysis of ergot alkaloids.
1934Jacobs & Craig in Jrnl. Biol. Chem. CIV. 547 A new substance was obtained..which possessed both acid and basic properties and which we have named lysergic acid. 1961New Scientist 2 Nov. 278 The alkaloids of ergot are all derivatives of lysergic acid, an indole compound. 1964D. F. Downing in M. Gordon Psychopharmacol. Agents I. xiii. 572 Lysergic acid derivatives with biological activity are..known to occur both in fungi and higher plants. The most active hallucinogenic substance (LSD-25) has, however, been obtained only by synthesis from (+)-lysergic acid. 1969T. A. Ban Psychopharmacol. xviii. 347/1 Lysergic acid diethylamide, or, as commonly referred to, LSD25, is a synthetic product prepared from lysergic acid.
b. Used ellipt. for lysergic acid diethylamide, or (less commonly) any derivative of the acid.
1952Jrnl. Mental Sci. XCVIII. 314 High doses of glucose raising the blood sugar above 200 mgm. inhibit the action of lysergic acid (LSD. 25). 1954Brit. Jrnl. Psychol. XLV. 274 The visions produced by such drugs as mescaline and lysergic acid. 1955Sci. Amer. June 39/1 The creation of experimental psychoses with lysergic acid thus opens the way to studying treatments and the nature of mental illness. 1957J. S. Huxley Relig. without Revelation vii. 168 Mescalin and lysergic acid induce remarkable intensifications and modifications of consciousness, including often a sense of transcendence of self. 1958Sunday Times 1 June 7/5 Lysergic acid should be tried for its extraordinary property of resurrecting childhood. 1962[see LSD2]. 1964New Statesman 28 Feb. 347/3 (Advt.), Author seeks objective confirmation of subjective mystical experience under Lysergic Acid (LSD 25). 1969T. A. Ban Psychopharmacol. xviii. 348/1 Other lysergic acids. Besides LSD25 there are at least eight other lysergic acid derivatives with psychotomimetic properties. 1972Daily Tel. (Colour Suppl.) 11 Aug. 12/3 The acids, like the barbiturates and amphetamines, are synthetically produced, and the best known is lysergic acid, LSD.
Hence lysergic acid diethylamide |daɪˈɛθɪl-, daɪəˈθaɪləmaɪd|, the diethylamide of lysergic acid (in which the group {b1}N(C2H5)2 replaces the hydroxyl group of the acid), an extremely powerful synthetic hallucinogen which can produce profound changes in perception (esp. vision) and mood, with psychotic symptoms resembling those of schizophrenia, and which has been given orally in psychotherapy, usu. as the water-soluble tartrate, a colourless odourless powder; also called LSD2, lysergide.
1944Chem. Abstr. XXXVIII. 1502 With NHEt2 condensation gave d-lysergic acid diethylamide. 1950Diseases Nervous Syst. XI. 241/1 Occasionally, it was observed that patients were able to verbalize the repressed components of their conflicts during a toxic delirium. This led us to consider various drugs that might induce a transitory delirious state. It was during this search that the Sandoz Company called to our attention and made available d-lysergic acid diethylamide (L.S.D. 25). 1955Sci. News Let. 2 July 4/1 LSD, short for lysergic acid diethylamide, is a chemical that produces hallucinations and delusions in healthy persons like those in mental sickness. 1965New Scientist 22 Apr. 224/3 Lysergic acid diethylamide (LSD 25) and mescaline are..often called ‘psychotomimetic’, because some of the symptoms which they produce create certain resemblances to schizophrenic illness. 1967Economist 7 Oct. 20/1 The coming thing is lysergic acid diethylamide (LSD). 1969[see sense a above]. 1971Nature 29 Jan. 347/1 Small doses (∼ 100 µg) of lysergic acid diethylamide (LSD) taken orally cause hallucinations and distortions of visual perception in man. Ibid. 16 July 191/1 Lysergic acid diethylamide (LSD-25) is believed to cause chromosome abnormalities. |