| 释义 |
meclozine Pharm.|ˈmɛkləzɪn, -iːn|
Also meclizine.
[f. methyl + chlorine n. + piperazine.]
A piperazine derivative, C25H27N2Cl, which is an antihistamine drug used mainly as an anti-emetic, esp. in preventing motion-sickness, and is usu. given as the dihydrochloride, a white crystalline compound.
Meclozine is the name in the British Pharmocopœia, meclizine that in the Pharmacopeia of the U.S.A.
1955Jrnl. Pharmacol. & Exper. Therap. CXV. 483 From a perceptual-motor viewpoint there would seem to be no valid reason why operating personnel could not take advantage of the beneficial effects which cyclizine, meclizine and promethazine have upon motion sickness. 1957Brit. Pharmaceut. Codex 1954 Suppl. 39 Meclozine hydrochloride has the properties of the anti-histamine drugs. 1959Which? July 69/1 The 1 mg. of hyoscine protected over 80 per cent of the subjects from sea-sickness, and..this dose, for one hour, was significantly more effective than the cyclizine and meclozine. 1963Times 27 May 18/4 (Advt.), The thalidomide tragedy did not directly affect your Company, but one of our most widely prescribed products, which contains meclozine, is for use in pregnancy sickness... Near the end of the year meclozine itself came under criticism. 1965New Scientist 4 Nov. 328/2 Anti-histamines, containing meclizine, cyclizine and chlorcyclizine must now carry a strong warning label. 1971J. J. Burns in B. N. La Du et al. Fund. Drug Metabolism & Drug Disposition xvii. 361 Although large doses of chlorcyclizine and meclizine can induce malformations in laboratory animals, no evidence of harm to the human fetus has been reported. |