| 释义 |
mepacrine Pharm.|ˈmɛpəkrɪn, -iːn|
[perh. f. methyl + paludism + acridine.]
A tricyclic base, C23H30N3OCl, derived from acridine and usually administered in the form of its dihydrochloride dihydrate salt, which is a yellow crystalline compound formerly widely used in the treatment of malaria and now used mainly as an anthelmintic. Cf. atebrin, quinacrine.
1943Lancet 29 May 699/1 The only synthetic anti⁓malarial compound of any real value so far in general use is mepacrine. 1956W. Slim Defeat into Victory xvi. 352 The jaundice yellow of all our complexions as a result of the daily dose of mepacrine. 1962Lancet 29 Dec. 1387/2 A related drug, chloroquine, has proved superior to mepacrine in the suppressive treatment of malaria, rheumatoid arthritis, lupus erythematosus, and light eruptions. 1971B. W. Aldiss Soldier Erect 74 The site where hundreds of BORs had pretended to swallow the morning mepacrine tablet and instead had ground it underfoot, happily risking malaria in the exercise of their own free will. |