释义 |
methotrexate Pharm.|mɛθəʊ-, miːθəʊˈtrɛkseɪt| [Origin unknown.] 4-Amino-10-methylfolic acid, C20H22N8O5, an orange-brown powder which is a folic acid antagonist and is used in the treatment of tumours, esp. cancer and leukæmia.
1955Sci. News Let. 5 Feb. 88/2 The new drug is an anti-folic acid compound very similar to Aminopterin. It is called Methotrexate by its manufacturers, Lederle Laboratories, Pearl River, N.Y. 1961[see mercapto-purine s.v. mercapto-)]. 1970Times Lit. Suppl. 26 Mar. 332/4 Burkett's [read Burkitt's] tumour..can be treated easily and successfully by dosing with methotrexate. 1971Nature 22 Oct. 518/3 The Food and Drug Administration has decided to allow the controversial drug methotrexate to be used for severe cases of psoriasis. 1973Brit. Pharmacopœia 300/1 Methotrexate. |