| 释义 |
nalorphine Pharm.|ˈnæləfiːn|
[f. N-allylnormorphine, another name for the compound (see quot. 19532).]
A heterocyclic base, C19H21NO3 (or its hydrobromide salt), which is very similar to morphine in chemical structure and is used as an antagonist for that drug and for other narcotics with a similar action.
1953Jrnl. Pharmacol. & Exper. Therap. CIX. 157 N-allylnormorphine (nalorphine) has been shown to have a specific respiratory stimulating effect against the depression caused by morphine,..codeine, methadone. 1953Proc. R. Soc. Med. XLVI. 927 N-Allylnormorphine is now officially called nalorphine... A methyl group is removed from the nitrogen [of morphine], hence the term nor from the German ‘Nitrogen ohne radicale’. An allyl group is substituted. 1967Martindale's Extra Pharmacopoeia (ed. 25) 838 Given apart from narcotics, nalorphine may itself cause respiratory depression and disturbing psychotic effects. 1968J. H. Jaffe in D. H. Efron Psychopharmacol. viii. 854/1 Nalorphine has virtually no abuse potential; its subjective effects are not ‘liked’ by post-addicts; it does not relieve morphine withdrawal symptoms, but instead precipitates them, and when given over long periods in high doses it produces an atypical physical dependence in which withdrawal symptoms are not associated with craving. 1971H. W. Elliott in D. H. Clouet Narcotic Drugs xxvi. 484 The pharmacological basis for the nalorphine test is an antagonism between nalorphine and the morphine-like drugs, which can be detected by examining the pupil. |