| 释义 |
notatin Biochem.|nəʊˈteɪtɪn|
[f. L. notāt-us, pa. pple. of notāre to mark, note v.2 + -in1.]
A flavoprotein produced by the mould Penicillium notatum which is an enzyme that catalyses the direct oxidation of glucose to gluconic acid and hydrogen peroxide and is used in the detection and estimation of glucose; = penatin, penicillin A, B.
1942C. E. Coulthard et al. in Nature 28 Nov. 634/2 When a selected strain of Penicillium notatum Westling is grown on a Czapek-Dox medium an anti-bacterial substance is produced which differs in the majority of its properties from penicillin. This anti-bacterial substance was originally named ‘Penicillin A’, but in order to avoid confusion with penicillin we now prefer the name ‘notatin’. 1949N. G. Heatley in H. W. Florey et al. Antibiotics I. iii. 136 For the assay of ‘notatin’ (known also as ‘penicillin B’ or ‘penatin’) the medium must contain glucose, for this so-called antibiotic is an enzyme..and exerts its effect purely through the hydrogen peroxide which is formed. 1954A. White et al. Princ. Biochem. xii. 264 A curious example of an antibiotic isolated from the mold Penicillium notatum is the substance notatin, which was later found to be the enzyme glucose oxidase containing flavin adenine dinucleotide. 1963R. Bentley in P. D. Boyer et al. Enzymes (ed. 2) VII. xxiv. 568 The following materials, originally described as antibiotics, are actually enzymes similar to, or identical with, the glucose oxidase of Müller: notatin (originally penicillin A).., penatin.., and penicillin B. Ibid. 569 Much of the work described in this chapter has been carried out with purified preparations of notatin, and an unqualified reference to glucose oxidase in the rest of this chapter will indicate notatin. |