| 释义 |
osteogenesis|ˌɒstɪəʊˈdʒɛnɪsɪs|
[f. osteo- + Gr. γένεσις genesis.]
a. The genesis, origination, or formation of bone.
1830R. Knox Béclard's Anat. 260 The formation of the bones, ossification, or osteogenesis is a phenomenon which has much occupied the attention of observers. 1842E. Wilson Anat. Vade M. (ed. 2) 5 This..constitutes the gelatinous state of osteo-genesis. 1882Nature XXV. 476 An exceptional form of osteogenesis, viz. metaplastic ossification, or direct transformation of cartilage into bone. 1950A. W. Ham Histol. xvi. 192/2 The formation of bone is usually spoken of as ossification or osteogenesis. 1963Jubb & Kennedy Path. Domestic Animals I. i. 9/2 Alkaline phosphatase..is very active in osteogenesis.
b. osteogenesis imperfecta [mod.L. (W. Vrolik Tabulæ Illustrandam Embryogenesin Hominis et Mammalium (1849) tab. 91)], an inherited disease characterized by extreme weakness of the bones, which break frequently even before birth.
1903Amer. Jrnl. Med. Sci. CXXV. 762 The disease called by Vrolik and by Stilling osteogenesis imperfecta, which previously in all probability was classed under fœtal rickets, is a definite, intrauterine process, the chief characteristics of which are great brittleness and softness of the bones, numerous fractures, and resulting deformities, due to as yet obscure disturbances of myelogenic and periosteal bone formation. 1923Brit. Jrnl. Surg. XI. 737 Osteogenesis imperfecta is the name given to a disease which is characterized by a congenital defect in the evolution of the osteoblast, and recognized clinically by defective ossification of the cranium and a multiplicity of fractures resulting from trivial causes. 1974Passmore & Robson Compan. Med. Stud. III. ii. xlv. 47/1 Osteogenesis imperfecta congenita is easily distinguished from achondroplasia but unnaturally short limbs, the result of prenatal fractures, create a superficial resemblance.
So osteogeˈnetic, osteoˈgenic, osteˈogenous (rare) adjs., of or pertaining to osteogenesis; bone-forming; osteˈogeny, osteogenesis.
osteogenetic cells, the same as osteoblasts. osteogenetic or osteogenic layer, the inner layer of the periosteum, concerned in the production of osseous tissue, consisting of loosely-meshed white fibres (osteogenic fibres) including osteoblasts. osteogenic or osteogenous substance, osteogenic tissue, that which composes the osteogenic fibres. (Syd. Soc. Lex.)
1736R. Nesbitt (title) Human Osteogeny explained in two lectures read before the surgeons of London in 1731. 1741Monro Anat. Bones (ed. 3) 39 The Knowledge of this Part of the Osteogeny..I think necessary. 1847–9Todd Cycl. Anat. IV. 647/2 Osteogenie is constant to the laws of serial order. 1857Mayne Expos. Lex., Osteogeneticus,..bone-generating; of or belonging to Osteogenesis,..osteogenetic. 1867Quain's Elem. Anat. (ed. 7) I. p. cv, This soft transparent matter, which becomes ossified, may..be distinguished by the name of ‘osteogenic substance’, as proposed by H. Müller, or simply of ‘osteogen’. 1874A. E. J. Barker tr. Frey's Histol. & Histochem. of Man 258 It is easy to recognise here..the similarity of the osteogenetic process to that in other parts of the system. 1905J. S. Ferguson Normal Histol. xi. 177 The osteogenous tissue of this layer, containing osteoblasts, osteoclasts, and developing blood vessels, grows into the cartilage. 1931M. Sinclair Fractures xv. 180 Certain forms of ununited fractures may be stimulated towards union by the presence of actual osteogenetic tissue in a bone graft. 1947Radiology XLIX. 310/2 Similar osteo⁓genic sarcomas were described in persons poisoned with radium for eight to ten years. 1951S. Gilder tr. Lacroix's Organization Bones xv. 204 Autoplastic grafts of marrow are osteogenic in adult animals as well as in young animals. 1975Nature 29 May 373/3 It was felt that statistical analysis could be based only on that bone tumour type for which solid prognostic data exist, agreed by all to be classical osteogenic sarcoma. |