| 释义 |
oxamniquine, n. Pharm.|ɒkˈsæmnɪkwiːn|
[f. oxy- + -amni- (perh. f. rearrangement of amino-) + quinoline n.]
An anthelmintic drug given orally in the treatment of schistosomiasis caused by Schistosoma mansoni infestation; 1, 2, 3, 4-tetrahydro-2-isopropylaminomethyl-7-nitro-6-quinolyl-methanol, C14H21N3O3 .
1972Approved Names (Brit. Pharmacopœia Commission) Suppl. iv. 5 Oxamniquine. 1973Trans. R. Soc. Trop. Med. & Hygiene LXVII. 679 Puerto Rican worms derived from the survivors of treatment of a previous generation with a sub-curative dose of oxamniquine were as susceptible to the drug as were their parents. 1979Nature 14 June 574/3 Oxamniquine will be given to 12 million people (already between 1 and 2 million have been treated) whereas provision of sanitation is planned for only 2.6 million. 1985Ann. Rev. Pharmacol. & Toxicol. XXV. 489 In every case where hycanthone-resistant S[chistosoma] mansoni worms have been isolated from either man or animals, they have been found to be resistant to oxamniquine also. |