| 释义 |
paromomycin Pharm.|ˌpærəʊməʊˈmaɪsɪn|
[f. Gr. παρόµοιος closely resembling (f. παρ- (see para-1) + ὅµοιος resembling): see -mycin.]
A broad-spectrum antibiotic that is a mixture of the sulphates of certain substances (chemically related to neomycin) produced by some strains of the bacterium Streptomyces rimosus, and is given orally in the treatment of intestinal infections. Also called paromomycin sulphate.
1956Brit. Pat. 797,568 Paromomycin is a stable amorphous white substance which is very soluble in water, moderately soluble in methanol and sparingly soluble in absolute ethanol. 1964M. Hynes Med. Bacteriol. (ed. 8) x. 138 Kanamycin..and paromomycin..are chemically similar to neomycin (and streptomycin) and have much the same properties. 1969J. H. Thompson in J. A. Bevan Essent. Pharmacol. li. 545 Paromomycin sulphate (Humatin) is usually prescribed as 10 to 25 mg per kilogram per day. Ibid., Paromomycin has been used in the treatment of intestinal amebiasis, trichomoniasis, some types of bacterial dysentery, preoperatively to suppress the colonic flora, and in hepatic coma and precoma. 1974Indian Jrnl. Med. Res. LXII. 495 Streptomycin and paromomycin were selected for treatment of cholera carriers at Hong-kong. |