| 释义 |
penicillinase Biochem.|pɛnɪˈsɪlɪneɪz, -s|
[f. prec. + -ase.]
Any of the enzymes (produced by certain bacteria) which cause the breaking up of the carbon-nitrogen bond in the lactam ring of some penicillins (so rendering them ineffective as antibiotics). Cf. lactamase.
1940Abraham & Chain in Nature 28 Dec. 837/1 The activity of the enzyme, which we term penicillinase, is slight at pH5, but increases considerably towards the alkaline range of pH. 1958Ann. Rev. Biochem. XXVII. 176 Cephalosporin-C possesses the interesting property of being resistant to the action of some penicillinases including that produced by penicillin resistant staphylococci. 1971[see lactamase]. 1974M. C. Gerald Pharmacol. iv. 72 Recent research has made available new penicillins that are resistant to acid hydrolysis and penicillinase attack. 1975Nature 12 June 526/1 Penicillinases, or as they are now known, β-lactamases, are enzymes which specifically deactivate penicillin by hydrolysis of the β-lactam ring. |