| 释义 |
pethidine Pharm.|ˈpɛθɪdiːn|
[f. piperidine with insertion of eth from ethyl, methyl.]
A narcotic analgesic (usu. given, orally or intramuscularly, as the hydrochloride, a colourless crystalline compound) which has actions similar to those of morphine but of shorter duration and is less addictive; ethyl 1-methyl-4-phenylpiperidine-4-carboxylate, C15H21NO2.
1942Lancet 22 Aug. 234/2 Pethidine hydrochloride, a synthetic compound closely allied to morphine in composition, and combining the analgesic effect of morphine with the spasmolytic effect of the atropine group and papaverine, is issued by Roche Products. 1942Ibid. 24 Oct. 487 Fairly recent..is the carboxylic acid ethyl ester of 1-methyl-4-phenylpiperidine, officially named pethidine by the GMC a year ago and known on the continent as ‘Dolantin’ and in the United States as ‘Demerol’. 1947Daily Tel. 1 Mar. 3/4 Several bottles found in the man's room were marked ‘pethidine’. 1955Times 2 July 4/3 The annual Government report to the United Nations..estimates that there are 317 known drug addicts... Heroin and pethidine were used by 17 per cent. and 16 per cent. respectively. 1962[see meperidine]. 1972Nature 15 Dec. 411/2 Hysterotomy patients received pethidine 100 mg postoperatively for analgesia. 1974M. C. Gerald Pharmacol. xiii. 247 Meperidine or pethidine, as this drug is more commonly called outside the United States, was fortuitously discovered in 1939 as the result of a search for atropine-like agents possessing antispasmodic activity. This compound was the first totally synthetic narcotic analgesic agent. |