| 释义 |
phenothiazine Pharm.|fiːnəʊ-, fɛnəʊˈθaɪəziːn|
Formerly also phenthiazine.
[f. pheno- + thio- + azine.]
a. A green, crystalline, heterocyclic compound, C12H9NS, which is used in veterinary medicine in the treatment of parasitic infestations.
b. Any of various derivatives of this, which constitute an important class of tranquillizing drugs used esp. in the treatment of mental illnesses.
1894G. M'Gowan tr. Bernthsen's Text-bk. Org. Chem. (ed. 2) 539 Nile Blue springs from naphtho-phenoxazine; and the thionine dyes from phen-thiazine. 1917Chem. Abstr. XI. 3903 (Index), Phenothiazine. 1926H. G. Rule tr. J. Schmidt's Text-bk. Org. Chem. 709 Phenthiazine, thio-diphenylamine,..is also the parent compound of a number of dye-stuffs. 1940Nature 17 Aug. 232/2 Since phenothiazine is a new and valuable vermifuge, its effect on animal tissues is of some general interest. 1959Times 14 Sept. 19/4 The nodula worm of sheep has been completely eliminated..by the use of pheno-thiazine during the period of winter housing. 1969Daily Tel. 1 Nov. 2/7 Large doses of phenothiazines induce a Zombi-like rigidity. 1974M. C. Gerald Pharmacol. iv. 71 The phenothiazine nucleus has proved..a rather versatile progenitor of pharmacologically useful compounds. Ibid. xvi. 301 Chlorpromazine (Thorazine), the most commonly employed phenothiazine. |