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protoˈporphyrin Chem.
[a. G. protoporphyrin (Fischer & Lindner 1925, in Zeitschr. f. physiol. Chem. CXLII. 147): see proto- and porphyrin.]
Any of a group of fifteen isomeric porphyrins, C34H34N4O4, in which the porphin nucleus has four methyl, two vinyl, and two propionic acid substituents; one isomer (protoporphyrin IX) occurs widely in living organisms, notably as hæm (its ferrous chelate derivative).
1925Chem. Abstr. XIX. 1714 The esters of ooporphyrin, Kämmerer's porphyrin, Papendieck's porphyrin and CO2- and HCI-porphyrins are identical... The name ‘proto-porphyrin’ is proposed for all of these. 1937Jrnl. Biol. Chem. CXVIII. 521 Probably the most important porphyrin in nature is protoporphyrin IX... There are fifteen possible isomers of this compound, but this one..is the only one so far demonstrated in nature. 1961Lancet 26 Aug. 450/2 This man..produced no abnormal quantity of uroporphyrin but excessive amounts of protoporphyrin which were localised mainly within his circulating red cells. 1964A. White et al. Princ. Biochem. (ed. 3) xlii. 792 A common pathway exists for the synthesis of heme and of chlorophyll leading to formation of protoporphyrin IX... Insertion of iron into the latter results in heme formation. In plants, in addition to synthesis of heme, magnesium is inserted into protoporphyrin IX to form magnesium protoporphyrin, which is converted in plastids to chlorophyll. 1975Nature 26 June 706/1 The prosthetic group of haemoglobin has a protoporphyrin structure (ferrohaem) in which the ion atom is ionically bound.
Hence ˌprotoporˈphyria Med., the presence of protoporphyrin in the red blood cells.
1956in New Gould Med. Dict. (ed. 2) 975/1. 1961 I. A. Magnus et al. in Lancet 26 Aug. 451/2 The absence of uroporphyrin clearly distinguishes this syndrome from congenital porphyria. It seems to be a hitherto undescribed erythropoietic condition for which we suggest the name ‘erythropoietic protoporphyria’. 1975Sci. Amer. July 73/1 Investigators can easily induce these typical symptoms without serious consequences in patients suffering from mild forms of erythropoietic protoporphyria, so that the disease is one of the few of its kind where the action spectrum for a direct effect of light has been studied in detail. 1977Proc. R. Soc. Med. LXX. 572/2 Erythropoietic protoporphyria (EPP) is a disorder, usually of autosomal dominant inheritance, in which large amounts of protoporphyrin are found in erythrocytes. |