| 释义 |
puromycin Biol. and Pharm.|pjʊərəʊˈmaɪsɪn|
[f. purine + -o + -mycin.]
An antibiotic which is produced by the fungus Streptomyces albo-niger and is used esp. to treat sleeping sickness and amœbic dysentery.
1953C. W. Waller in Jrnl. Amer. Chem. Soc. LXXV. 2025/1 The new antibiotic, Puromycin, isolated from the mold Streptomyces alboniger, has been found to be active against certain bacteria and Trypanosomes. 1960M. E. Florey Clinical Applications of Antibiotics IV. vi. 162 Puromycin..had the unique advantage of not only arresting the growth of trypanosomes but also of being able to kill them. 1968W. Hayes Genetics of Bacteria & their Viruses (ed. 2) xii. 288 Puromycin has a close structural resemblance to the terminal amino-acyl adenosine of t-rna and interferes with protein synthesis, both in vivo and in vitro, by inserting itself at ribosomal slot No. 2 [etc.]. 1978Bio Systems X. 194/1 Puromycin is another commercially available antibiotic which, because of its toxicity, is not used therapeutically but rather as a research tool. |