| 释义 |
butyrophenone, n. Chem. and Pharm.|ˌbjuːtɪrəʊfɪˈnəʊn, -ˈfɛnəʊn|
[f. butyro- + -phenone (f. phenyl n. + ketone n.).]
n-Propyl phenyl ketone, C6H5·CO·(CH2)2CH3 , a liquid. Also, any compound whose structure contains this group.
1908Chem. Abstr. II. 1426 With C6H6 and AlCl3 it forms the butyrophenone, C8H4O2: NCH2CH2CH2Bz ; flat, pointed needles, 132-3°. 1917Ibid. XI. 3753/2 Butyrophenone, CH3CH2CH2COPh . 1961Jrnl. Pharmaceutical Sci. L. 350/1 On synthesizing a series of over 1,000 new substituted piperidines, it was found that the basic butyrophenones therein had powerful C.N.S.-depressant activity in various species. 1967I. L. Finar Org. Chem. (ed. 5) I. xxvii. 707 Willgerodt reaction...The amido-group is always formed at the end of the chain whatever the size of the R group in C6H5·CO·R ; e.g., butyrophenone forms γ-phenylbutyramide... C6H5·CH2·CH2·CH2·CONH·2 . 1968Brit. Med. Jrnl. 27 Apr. 230/2 The butyrophenone derivatives are non-phenothiazine drugs which are useful in the treatment of psychotic patients, particularly those with manic overactivity. 1984Brit. Nat. Formulary VIII. 139/2 Drugs of other chemical groups tend to resemble the phenothiazines... They include the butyrophenones (benperidol, droperidol, haloperidol, and trifluperidol); [etc.]. |