| 释义 |
pyrimethamine Pharm.|pɪrɪˈmɛθəmiːn|
[f. pyrimidine + ethyl + amine.]
A white crystalline solid, 2,4-diamino-5-p-chlorophenyl-6-ethylpyrimidine, C12H13N4Cl1 which is given orally for the prophylaxis and suppression of malaria.
1953Brit. Med. Jrnl. 31 Jan. 253/1 Pyrimethamine..is the latest of the new synthetic anti-malarial drugs to be tested by us... This compound is produced by Burroughs Wellcome & Co. under the trade name ‘daraprim’. 1961New Scientist 20 Apr. 120/1 Pyrimethamine resistance has appeared in some districts in East Africa. 1966Lancet 24 Dec. 1382/1 The combination of dapsone to shorten the red-blood-cell life-span and pyrimethamine to inhibit erythropoiesis has now been used successfully on five patients with secondary polycythæmia. 1976Ibid. 4 Dec. 1257/1 When a dose of 25 mg weekly is taken for malarial prophylaxis, pyrimethamine is unlikely to produce adverse hæmatological effects except in those actually or potentially folate deficient. |