| 释义 |
cimetidine, n. Pharm.|saɪˈmɛtɪdiːn|
[f. ci-, alteration of cyano-, + methyl n. + -idine.]
An imidazole derivative, C10H16N6S , with histamine H2 -receptor blocking properties, given (usu. in tablet form as the hydrochloride) in the treatment of peptic ulcers.
1975Brit. Jrnl. Pharmacol. LIII. 435 P/2 In male human volunteers cimetidine given intravenously has been shown to inhibit histamine- or pentagastrin-stimulated gastric secretion. 1977Lancet 9 July 74/2 The third therapeutic approach involves antacids and drugs such as the H2 -receptor blockers metiamide and cimetidine which inhibit gastric secretion. 1986C. W. Thornber in C. A. Heaton Chem. Industry iv. 177 Cimetidine..is currently the world's top selling drug. 1989Brit. Med. Jrnl. 6 May 1266/1 H2 receptor antagonists like cimetidine have reduced the need for hospital admission and for surgery in patients with uncomplicated duodenal ulcer. |