| 释义 |
Skraup Chem.|skraʊp|
The name of Zdenko Hans Skraup (1850–1910), Czech chemist, used attrib. and in the possessive to denote a reaction which he discovered (Sitzungsber. der K. Akad. der Wissensch. (Math.-Nat. Classe) (1880) LXXXI. ii. 593), in which a quinoline is synthesized by heating a primary aromatic amine with glycerol, sulphuric acid, and an oxidizing agent.
1886Jrnl. Chem. Soc. L. 79 Chloromethylquinoline..is prepared by Skraup's method from parachlorometa⁓toluidine. 1935L. F. Marek in P. H. Groggins Unit Processes in Org. Synthesis vii. 350 Quinoline is prepared from aniline and glycerol by the Skraup reaction. 1954I. L. Finar Org. Chem. (ed. 2) I. xxxi. 691 Alizarin Blue..may be prepared by first reducing Alizarin Orange to the corresponding amino-compound and then heating this with glycerol, sulphuric acid and nitrobenzene (Skraup's synthesis). 1975R. F. Brown Org. Chem. xxviii. 908 The Skraup synthesis involves a dehydration, a Michael addition, an electrophilic substitution (the ring-closing reaction), and an oxidation, all occurring in one flask during a relatively short period of refluxing. |