| 释义 |
radioimmuno-|ˌreɪdɪəʊˈɪmjuːnəʊ, -ɪˈmjuːnəʊ|
[f. radio- 2 + immuno-.]
Formative element in terms pertaining to analytical techniques combining immunological and radioisotopic methods. (In the following words secondary stresses vary as indicated above, and are not in general marked in each word.)
radioimmunoˈassay, an immunological assay in which the test sample is determined by allowing it to react with a prepared antiserum in competition with a known quantity of radioisotopically labelled antigen, the extent of reaction being measured from the amount of radiation emitted (see quot. 1974); hence radioimmunoˈassayable a., capable of determination by radioimmunoassay; radioimmunoˈchemical a., deriving both from immunology and from radiochemistry; employing radioisotopically labelled antigens and antibodies as reagents for chemical analysis; hence radioimmunoˈchemically adv.; radioimmunoeˌlectrophoˈresis, immuno-electrophoresis carried out using radioisotopically labelled samples, usu. as a means of studying the formation or binding of proteins; so radioimmunoeˌlectrophoˈretic a.; radioimmunoprecipiˈtation, the use of radioisotopically labelled antigen or antibody in a precipitin test, the radioactivity in any precipitated complex being measured.
1961Jrnl. Clin. Investigation XL. 1086/1 A specific radioimmunoassay of human growth hormone..has been devised. 1966Lancet 24 Dec. 1389/2 Glucose was measured by the potassium-ferricyanide method..and insulin by radio-immunoassay. 1974R. M. Kirk et al. Surgery ii. 36 To carry out radioimmunoassay, an antiserum is first raised by injecting the substance repeatedly into laboratory animals, and later withdrawing serum containing antibody. A known concentration of antigen, labelled with a radioactive marker, is placed in competition with the test serum for combination with the antibody. 1977Time 24 Oct. 52/1 Yalow and her late collaborator, Dr Solomon Berson, devised a sensitive new biological analytic technique called the radioimmunoassay (RIA).
1973Nature 27 July 230/1 The serum level of radioimmunoassayable (RIA) growth hormone. 1978Ibid. 12 Jan. 178/2 The radioimmunoassayable enkephalin content of the basal ganglia does not change after cortical ablation.
1968Gastroenterology LV. 317/2 The supernatant solutions were analyzed in triplicate for gastrin by a radioimmunochemical technique Ibid. 326/2 The gastrin contents..were measured radioimmunochemically. 1977Lancet 26 Mar. 666/2 Blood obtained by antecubital-vein puncture was assayed radioimmunochemically for insulin, glucagon, gastrin, and pancreatic polypeptide.
1962Morse & Heremans in Jrnl. Laboratory & Clin. Med. LIX. 893 This method of immunoelectrophoresis, followed by autography, will be referred to as radioimmunoelectrophoresis. 1970Nature 12 Dec. 1086/2 Radioimmunoelectrophoresis was also performed on dialysed supernatant from cell cultures incubated with either amino-acids labelled with 14C or with reconstituted protein hydrolysate similarly labelled. 1975Ibid. 11 Dec. 547/2 Radioimmunoelectrophoresis of serum from snakes injected with HEA revealed that the gamma precipitin line specifically bound HEA131I.
1962Jrnl. Immunol. LXXXIX. 744/2 Similar radio immunoelectrophoretic technique was applied in insulinbinding antibodies from human patients. 1962Jrnl. Clin. Investigation XLI. 260/1 Our observations with radioimmunoprecipitation confirm the information obtained with more orthodox immunologic procedures. 1971Jrnl. Immunol. CVI. 1167/1 The radioimmunoprecipitation test (RIP) was performed by the microtiter method as modified by Sever..using V-bottom thin plastic plates. 1974Nature 25 Jan. 176/3 In addition the antigen was detected by radioimmunoprecipitation in the supernatant fluid of a few cultures which had been serially passaged. |