| 释义 |
cyclophosphamide Pharm.|saɪkləʊˈfɒsfəmaɪd|
[f. cyclo- + phosph- (in phosphoric acid) + amide.]
A fine white crystalline powder used as a cytotoxic drug in the treatment of tumours and some kinds of leukæmia, and usu. given intravenously or orally; 2-[di-(2-chloroethyl)-amino-]-1-oxa-3-aza-2-phosphacyclohexane 2-oxide, C7H15Cl2N2O2P.
1960Brit. Med. Jrnl. 24 Dec. 1837/1 We report our experiences in the treatment of Hodgkins's disease and other tumours of lymphoreticular tissue with a cyclic nitrogen mustard phosphamide ester, cyclophosphamide. 1963Times 16 Feb. 5/4 A drug, cyclophosphamide,..killed some of the cells thought to be responsible for rejecting foreign tissue such as the newly grafted kidney. 1966Lancet 24 Dec. 1382/1 Cyclophosphamide was tried, unsuccessfully, in one patient, but this drug is known to be antagonised by dapsone. 1967Martindale's Extra Pharmacopoeia (ed. 25) 818/2 The most troublesome side-effect of cyclophosphamide therapy is alopecia. 1969Nature 1 Feb. 468/2 Cyclophosphamide shows promise as a method of removing the wool from sheep chemically. 1970Sci. Jrnl. Mar. 63/1 Modern drugs such as methotrexate and cyclophosphamide are extremely valuable in the treatment of many cancers and especially leukaemias. |