sul·fo·nyl·u·re·a 
(sŭl′fə-nĭl-y-rēə)
(sŭl′fə-nĭl-y-rēə)n.
Any of a group of hypoglycemic drugs, such as glyburide, that act on the beta cells of the pancreas to increase the secretion of insulin and are used in the treatment of type 2 diabetes.