de·range 
(d
ĭ-r
ānj
)
tr.v. de·ranged,
de·rang·ing,
de·rang·es 1. To disturb the order, arrangement, or functioning of: an asteroid impact large enough to derange the climate.
2. To upset (normal condition or functioning, as of a bodily organ).
3. To cause to be psychotic or otherwise severely mentally unsound.
[French déranger, from Old French desrengier : des-, de- + reng, line (of Germanic origin; see sker-2 in the Appendix of Indo-European roots).]
de·rangement n.