de·spite 
(d
ĭ-sp
īt
)
prep. In spite of; notwithstanding: won the game despite overwhelming odds.
n.1. Contemptuous defiance or disregard.
2. Spite; malice: "He died soon after ... of pure despite and vexation" (Sir Walter Scott).
[Short for in despite of, from Middle English despit, spite, from Old French, from Latin dēspectus, from past participle of dēspicere, to despise; see DESPISE.]