After ten rounds, participants are asked to propose their hypothesis about what the rule could be.

He proposed the hypothesis that at the onset of the disease, lack of appetite originates from a wish to avoid pain.

Funk proposed the hypothesis that other diseases, such as rickets, pellagra, coeliac disease, and scurvy could also be cured by vitamins.

In it, he proposed the hypothesis that natural selection could drive the reproductive isolation of two varieties by encouraging the development of barriers against hybridisation.