How our country operates and the decisions our leaders make have significant ramifications, for better or worse, for the rest of the world.

That this will have further significant ramifications seems not to be in doubt.

Over time, this will increase the cost of equity for growth companies, with significant ramifications for productivity and expansion.

This has had significant ramifications for human rights protection - a freeze on new posts, departing staff not replaced, human rights-monitoring activities put at risk, longer-term planning made difficult or impossible.

This first wave as it became known had some significant ramifications.