The inflammation and ulceration that occurs as a result of pathergy in pyoderma gangrenosum often responds to systemic steroid therapy.

In either case, steroid therapy has significant side effects.

Steroid therapy caused a worsening of the symptoms.

Several cases of progressive bilateral hearing loss unresponsive to steroid therapy have been described as an infrequent adverse reaction to hydrocodone/paracetamol misuse.

Chronic cases require steroid therapy, which generally leads to a good response.