Second, are such experiments sufficiently reliable anyway, given the physiological differences between species?

So far no simple home test has proved sufficiently reliable.

Yet to provide sufficiently reliable valuations, the process would become prohibitively expensive.

By 1959 discrete transistors were considered sufficiently reliable and economical that they made further vacuum tube computers uncompetitive.

Analytical methods generally can not capture all the details of the given reservoir or process, but are typically numerically fast and at times, sufficiently reliable.