This can occur in a susceptible individual as blood passes through cold extremities in cold weather.

The amount of the food substance required to provoke a reaction in a particularly susceptible individual can be quite small.

In some cases, eating certain foods may bring on acute spasms, in susceptible individuals.

In susceptible individuals, midazolam has been known to cause a paradoxical reaction, a well-documented complication with benzodiazapines.

When bruised, crushed or cut, the leaves and branches have a spicy resinous fragrance, which can cause respiratory discomfort in susceptible individuals.