Bony involvement can occur after soft tissue destruction.

Osteoclasts are also prominent in the tissue destruction commonly found in psoriatic arthritis and other rheumatology related disorders.

Malignant astrocytomas generate symptoms and signs by mass effect, local brain infiltration, tissue destruction, cerebral edema, and increased intracranial pressure.

Symptoms are mostly due to the body's immune response to the infection rather than to tissue destruction by the viruses themselves.

Large amounts of tissue destruction, or damage in tissues unable to regenerate, can not be regenerated completely by the body.