During suppression, neuronal pumps restore the calcium ion concentrations to normal levels, thus causing the cortex to be subject to the process again.

When in solution, the calcium ion varies remarkably to the human taste, being reported as mildly salty, sour, mineral-like or even soothing.

Also, annexins have been shown to be involved in trafficking and organization of vesicles, exocytosis, endocytosis and also calcium ion channel formation.

So long as internal calcium ion concentrations remain at an elevated level, the neuron will continue to undergo periods of rapid spiking.

The catalytic domain contains two zinc ions and at least one calcium ion coordinated to various residues.