The radiologist may end up sampling adjacent tissue instead.

The area differs in characteristics such as thickness and temperature as compared to adjacent tissue.

This weakens the leaflets and adjacent tissue, resulting in increased leaflet area and elongation of the chordae tendineae.

Primary tumor masses spawn pioneer cells that invade adjacent tissues, and may then travel to distant sites, and establish metastases.

Abnormal joint movement also creates many protective actions by adjacent tissues.