Only patients with advanced disease, with minimal vision, will be admitted to the trial.

And because younger people don't think it will happen to them they tend to ignore signs of trouble and present with more advanced disease.

Surgeons are even recommending exercise in people with advanced disease and who are on the waiting list for knee (and hip) replacement.

Both endoscopic surgery and conventional open-abdominal surgery have proven to be effective treatment modalities for patients with more advanced disease.

In advanced disease, hypoalbuminemia, hyperproteinemia, and hyperglobulinemia may be present.