Some factors that contribute to inadequate treatment are: early discontinuation of treatment, insufficient dosage of medication, patient noncompliance, misdiagnosis, and concurrent psychiatric disorders.

To avoid detection when police were brought in after patients experienced hypoglycaemic episodes, he sabotaged prescription charts to increase dosages of medication.

It may take up to two years to bring symptoms under control so that dosages of medication can be reduced.

Modern clinical guidelines identify, summarize and evaluate the highest quality evidence and most current data about prevention, diagnosis, prognosis, therapy including dosage of medications, risk/benefit and cost-effectiveness.