As long as a borrower can comfortably afford the mortgage and remain in work, the two factors are essentially irrelevant.

The subject of private medicine kept being tugged back to location and estate agents, who were essentially irrelevant and, at best, a distraction.

It can not, obviously, be ruled out, but it's essentially irrelevant.

For long-term investors, newspaper headlines about short-term losses are essentially irrelevant.

The name collenchyma in turn was borrowed from botany because of a fancied, essentially irrelevant, resemblance between sponge tissue and a particular class of ground tissue in plants.