These receptors are distinct from the growth hormone-releasing hormone receptors, and, thus, provide a means of controlling pituitary growth hormone release by the gastrointestinal system.

It colonizes the gastrointestinal system, predominantly the stomach.

Adenosine receptors are found throughout the body including the brain, in the cardiovascular, respiratory, renal and gastrointestinal system and in adipose tissue.

It causes vasoconstriction in many blood vessels, including those of the skin, gastrointestinal system, kidney (renal artery) and brain.

Additionally, the vagal and enteric nervous system inputs transmit information regarding the state of the gastrointestinal system.