It's as though they think they can prepare; intellectually prompt an antibody response.

Following transfusion, a subsequent robust antibody response in the patient can occur (anamnestic response), resulting in hemolysis of the transfused red blood cells.

Attempting to overcome this problem by repeated immunization results in a diminished not increased antibody response, so boosters are not recommended with this vaccine.

Passively acquired maternal antibodies can suppress the antibody response to active immunization.

Taking this information into consideration an ideal vaccine candidate would attempt to generate a more substantial cell-mediated and antibody response on parasite presentation.